Search results: “MAK”

This 30-minute webinar shows you how to make your own cell-based assays to analyze β-arrestin recruitment in any cell type.…

Learn how KILR® cytotoxicity assays provide a simple, non-radioactive and dye free method to specifically measure target cell death in…

Protein kinases are critical to many cellular pathways and play a role in several therapeutic areas such as oncology, inflammation,…

DiscoveRx’s PathHunter® platform is a simple, cell-based, chemiluminescent assay format that allows for screening large numbers of small molecules or…

A common feature of 7TM receptors is that upon activation, the receptors are bound by cellular Arrestin proteins. DiscoveRx has…

Orphan GPCRs continue to represent a target class with immense potential for the discovery of novel therapeutic compounds. In spite…

Class I therapeutic antibodies achieve their clinical efficacy not only by binding to their target antigen, but also through Fc…

Assays that directly detect compound binding inside cells can be of great utility in translating in vitro data to more…

Ubiquitin-mediated degradation of signaling proteins is a primary means of signal regulation in a wide variety of cellular processes including…

DiscoveRx has developed a novel application of our established Enzyme Fragment Complementation (EFC) technology that allows us to monitor protein-protein…

Ligand-induced receptor dimerization is the first functional step in receptor activation, representing the most proximal, functional read-out for receptor activation.…

Ligand-induced receptor dimerization is the first functional step in receptor activation, representing the most proximal, functional read-out for receptor activation.…