GPCR Functional ‘Volume Control’ in Cell Systems: Tuning Receptor Density & System Sensitivity to Define Compound Activity

How much of your compound's activity are your assays really detecting? Understanding how receptor density impacts pharmacological responses is critical for accurately characterizing compound activity & identifying candidates with the highest likelihood of therapeutic success. Review the latest GPCR white paper, "Functional 'Volume Control' in Cell Systems," by GPCR expert Terry Kenakin, Ph.D., Professor of Pharmacology at the University of North Carolina School of Medicine, in collaboration with Eurofins DiscoverX®. The white paper explores how tuning receptor density & system sensitivity can uncover hidden efficacies, improve characterization of agonists & antagonists, & provide more predictive pharmacology.