Control Ligands and Inhibitors

Ligands are small or large molecules that can bind to transmembrane receptor or intracellular protein targets such as enzymes and alter the state of the target molecule. These ligands can be a variety of molecules including small molecule chemicals, proteins such as growth factors and cytokines, as well as antibodies. In drug discovery and development, ligands are often used as probes to determine the ligand's mechanism of action (MOA), understand the target's function, or identify and screen potential drug targets.

Ligands can be classified as agonists, partial agonists, super agonists, allosteric modulators, or antagonists, depending on whether they activate, change, or inhibit the target protein they bind. When activating ligands bind to a target, the structure is altered. The binding may lead to the dimerization of a receptor and/or initiation of a cascade of cellular signal transduction events ultimately leading to a unique cellular response or phenotype. Many such cellular responses are vital for the proliferation, migration, survival, and differentiation of cells within all multicellular organisms. In contrast, inhibitor ligands typically block signaling. Inhibitors of intracellular proteins like enzymes fall under the reversible or irreversible types. While both types bind to the target protein, the reversible inhibitors dissociate from the target under certain conditions, whereas irreversible inhibitors do not. Overall, inhibitors play a significant role in drug discovery and are used to analyze cellular pathways and treat various disorders.

Choose from a variety of small molecules, peptides, and recombinant proteins as control ligands and inhibitors as well as antibodies and antibiotics that support Eurofins DiscoverX® cell-based assays for developing your target-based therapeutics development.

Product Highlights

  • Validated – Pre-validated reference ligands and inhibitors conveniently supplied with a recommended reconstitution buffer for use with Eurofins DiscoverX cell-based assays
  • Extensive Menu – Access over 300 control ligands and inhibitors, including small molecules, peptides, and recombinant proteins, to support small molecule or biologic drug discovery and development
  • Diverse Applicability – Determine ligands MOA, understand the function of targets, or identify and screen potential drug targets

Control Ligands and Inhibitors

  • Ligands and Inhibitors – More than 330 control ligands and inhibitors, including small molecules, peptides, and recombinant proteins to support your Eurofins DiscoverX cell-based assays.
  • PathHunter Antibodies – High-quality monoclonal antibodies specific for Enzyme Fragment Complementation (EFC) β-galactosidase fragments, enzyme donors ProLabel® and ProLink and enzyme acceptor, and optimized for a broad range of applications including Western Blot and immunofluorescence.

Access Products by Product Type and Ligand Name

Brochures & Flyers Eurofins DiscoverX – Delivering Solutions from Discovery to Market

Products & Custom Development Capabilities.

Read More
Cell Lines and Primary Cells

Stable cell lines, cell pools, frozen cells, & primary effector cells for a broad range of target classes

Read More
Detection Kits & Reagents

Kit & reagents for sensitive quantification of biologics or small molecules to provide accurate pharmacology & reproducible results

Read More
Build Your Own Assay Tools

Complete set of parental cell lines, vectors, kits, & retroparticles to build your own stable cell lines & cell-based assays

Read More
Recombinant Proteins and Enzymes

Over 500 high-quality & purified recombinant kinases, phosphatases, & epigenetic & ubiquitin proteins

Read More
Custom Capabilities

Custom cell lines, kits, assays, & protein development capabilities optimized to fit your requirements

Read More