Showing 1–12 of 81 results
Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific enzyme that regulates the signaling molecules that control synaptic plasticity and neuronal…
Read MoreMast cells play key roles in allergy, anaphylaxis/anaphylactoid reactions, and defense against pathogens/toxins. These cells contain cytoplasmic granules with a…
Read MoreBy suppressing gene transcription through the recruitment of corepressor proteins, B-cell lymphoma 6 (BCL6) protein controls a transcriptional network required…
Read MoreBromodomain protein 4 (BRD4), a member of the bromodomain and extra-terminal (BET) proteinfamily, acts as a central element in transcriptional…
Read MoreEndogenous mechanisms that orchestrate resolution of acute inflammation are essential in host defense and the return to homeostasis. Resolvin (Rv)D2…
Read MoreA novel and growing modality in drug discovery has been the application of Targeted Protein Degradation (TPD). TPD involves the…
Read MoreSPRINTer™ protein turnover biosensor assays overview. Keystone 2021 Poster Presentation. 5 min.
Watch NowLearn how to easily detect target protein turnover induced by targeted degrader molecules, such as PROTACs (trademark of Arvinas). Discover…
Watch NowDiscoveRx has developed a panel of over 120 characterized GPCR cell lines that monitor receptor activity using interaction with human…
Read MoreDiscoveRx’s PathHunter® platform is a simple, cell-based, chemiluminescent assay format that allows for screening large numbers of small molecules or…
Read MoreDiscoveRx has pioneered a novel enzyme complementation system to monitor cellular events such as protein translocation, protein interactions, and degradation…
Read MoreAn assay platform that robustly and sensitively quantifies the kinetics of endogenous protein turnover and target engagement is crucial for…
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