Search results: “RANK”

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Publications InCELL Target Engagement: A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1

A persistent problem in early small-molecule drug discovery is the frequent lack of rank-order correlation between biochemical potencies derived from…

Videos InCELL Compound-Target Engagement Assays for Drug Discovery

Learn how InCELL cell-based binding assays can be used to detect compound cell entry and engagement to specific targets including…

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Videos Reporter Assays for Therapeutics Targeting Signaling Pathways

Learn how PathHunter signaling reporter assays can be used to evaluate the cellular impact of therapeutics targeting a variety of…

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Case Studies Implementing Robust & Reproducible KILR® Ready-to-Use Bioassays from Screening to Lot Release: Applications for Measuring Direct Cytotoxic Cell Death

Therapeutic regulators require assay data on the impact of Fc effector-mediated function of antibodies during their development as therapeutics. The…

Scientific Posters Development and Evaluation of a Novel Bioassay for Denosumab Activity

Denosumab (Prolia®) is a fully human sequence derived monoclonal antibody used for the treatment of osteoporosis in menopausal women via…

Scientific Posters A Novel Assay Platform for the Detection of Kinase-Inhibitor Binding in Intact Mammalian Cells

Assays that directly detect compound binding inside cells can be of great utility in translating in vitro data to more…