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Qualification Data cAMP Hunter Tirzepatide GLP-1 RA Bioassay Qualification Data

Publications Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions

Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs…

Publications Comparison of four in vitro cytotoxicity assays for assessing the potency of CD3-bispecific antibodies redirecting T cells to kill tumor target cells

Evaluation of cytotoxicity is a critical step in the selection of CD3-bispecific antibodies (BsAbs) for cancer immunotherapy.

Publications The First WHO International Standard for Harmonizing the Biological Activity of Bevacizumab

Several Bevacizumab products are approved for clinical use, with many others in late-stage clinical development worldwide. To aid the harmonization…

Qualification Data Liraglutide Bioassay Kit Qualification Data

Blogs & Articles Evaluate GLP-1R Targeted Therapeutics using First-to-Market Semaglutide Qualified GLP-1R Bioassay

Glucagon-Like Peptide-1 (GLP-1), a member of the glucagon-secretin peptide family, is secreted from L-cells of the small intestine and binds…

Videos Single Donor-Derived KILR CD16 Effector Cells for ADCC and T Cell Redirection Applications

Learn how KILR CD16 effector cells ensure assay reproducibility with higher signal-to-background ratios, without worrying about donor variability. PBMC effector…

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Videos A Novel MOA-reflective Bioassay for Quantifying Potency of Therapeutics Targeting the SIRPα|CD47 Signaling Axis

Learn about the first commercially available SIRPα/CD47 cell-based assay — PathHunter SIRPα Signaling Assay. Find out more about the generation…

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Case Studies Implementing Robust & Reproducible KILR® Ready-to-Use Bioassays from Screening to Lot Release: Applications for Measuring Direct Cytotoxic Cell Death

Therapeutic regulators require assay data on the impact of Fc effector-mediated function of antibodies during their development as therapeutics. The…

Webinars Driving Robust ADCC and T Cell Redirection with KILR CD16 Effector Cells

PBMC effector cells have inherent donor variability, reducing their consistency and reproducibility in lot release assays. Antibody-Dependent Cell Cytotoxicity (ADCC)…

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Webinars Establishing Qualified Bioassays for Checkpoint Receptors to Implement in QC Lot Release: Case Studies on PD-1 and SIRPα

Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, which is often exploited…

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Webinars Cytotoxicity Bioassays – Measuring Antibody-Mediated Direct Cell Death

The webinar focusses on measuring antibody-mediated cell death using DiscoverX’s KILR Bioassays, and how they can be used to measure…

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