Case studies on the use of cell-based assays that monitor receptor dimerization and signaling reporter activation targeting IL-12, IL-23, IL-15,…
Read MoreSearch results: “Arg”
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Jennifer Lin-Jones, Ph.D., Associate Director of Assay Development R&D Department, Eurofins DiscoverX
Read MoreWatch this webinar to discover functional cell-based assays for characterizing novel therapeutics & biosimilars targeting cytokines in inflammation & oncology.
Watch NowStriatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific enzyme that regulates the signaling molecules that control synaptic plasticity and neuronal…
Read MoreThe clinical success of an ever-increasing array of biologics has led to the development of a wide spectrum of immunomodulatory…
Read MoreA persistent problem in early small-molecule drug discovery is the frequent lack of rank-order correlation between biochemical potencies derived from…
Read MoreA Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)
Read MoreThe non-receptor protein tyrosine phosphatase (PTP) SHP2 is encoded by the proto-oncogene PTPN11 and is a ubiquitously expressed key regulator…
Read Moreβ-Arrestins are ubiquitously expressed in all cell types, and function in the desensitization of G- protein coupled receptors (GPCRs), the…
Read MoreEvaluation of cytotoxicity is a critical step in the selection of CD3-bispecific antibodies (BsAbs) for cancer immunotherapy.
Read MoreMost therapeutic antibodies have a Fab’ region that binds the antigen, and an Fc region which binds to and activates…
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