| Biological Information | |
|---|---|
| Background Information: | VHR protein is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotryosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer.
GenBank NM_004090 |
| Target Class: | Phosphatase |
| Accession Number: | NM_004090.2 |
| Target Name: | VHR |
| Target Aliases: | DUSP3, VHR |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
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VHR
N-terminal GST-tagged recombinant, full length VHR.
Datasheets
14-594x Datasheet
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