| Biological Information | |
|---|---|
| Background Information: | The Tie family of receptor tyrosine kinases comprises two members, Tie1 and Tie2 (Angiopoietin 1 receptor, Tyrosine-protein kinase receptor Tie-2, Tyrosine-protein kinase receptor TEK, P140 TEK, Tunica interna endothelial cell kinase, CD202b antigen, EC 2.7.1.112 ). These receptors are expressed predominantly in endothelial cells and are essential for vessel formation where they are required for the later stages of angiogenesis and vessel maintenance. Tie2 has roles in control of microvessel sprouting, integrity, and maturation. Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have been identified as ligands of Tie2 receptor, which may regulate endothelial cell proliferation, differentiation and guide the proper patterning of endothelial cells during blood vessel formation. Inhibitors of Tie2 may inhibit vascular healing and tumor angiogenesis. |
| Target Class: | Kinase |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | Tie2 |
| Target Aliases: | TEK, TIE2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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Tie2 (Y897S), active
N-terminal 6His-tagged recombinant, human Tie2 amino acids 771-end. The Y897S substitution is a gain-of-function mutation associated with hereditary venous malformations (Calvert et al., (1999), Hum. Mol. Genet. 8, 1279-1289).
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