| Biological Information | |
|---|---|
| Background Information: | N-terminal 6His-tagged recombinant, human Tie2 amino acids 771-end. Tyrosine 1108 has been identified as an autophosphorylation site in human Tie2. The Y1106F substitution in murine Tie2 (analogous to Y1108F in human Tie2) has been shown to block cell migration by disrupting binding of Tie2 to the docking protein Dok-R (Jones N., et al., Mol Cell Biol.(2003);23:2658-2668 and Murray B.W., et al., Biochemistry.(2001);40:10243-10253). |
| Target Class: | Kinase |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | Tie2 |
| Target Aliases: | TEK, TIE2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Tie2 (Y1108F), active
10 µg of active Tie2 (Y1108F). N-terminal 6His-tagged recombinant, human Tie2 amino acids 771-end.
Datasheets
14-766x Datasheet
View Document