| Biological Information | |
|---|---|
| Background Information: | N-terminal 6His-tagged recombinant, human Tie2 amino acids 771-end containing the R849W substitution. The R849W mutation has been reported in dominantly inherited venous malformations. Expression studies in insect and mammalian cells demonstrates that Tie2 R849W has constitutively elevated tyrosine kinase activity compared with wild type. (Morris P.N., et al., Biochem.Biophys.Res.Commun.(2006);346:335-338 and Vikkula M, et al., Cell(1996);87:1181-1190). |
| Target Class: | Kinase |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | Tie2 |
| Target Aliases: | TEK, TIE2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Tie2 (R849W), active
10 µg of active Tie 2 (R849W). N-terminal 6His-tagged recombinant, human Tie2 amino acids 771-end containing the R849W substitution.
Datasheets
14-763x Datasheet
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