| Biological Information | |
|---|---|
| Background Information: | SHP-1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
GenBank NM_002831 |
| Target Class: | Phosphatase |
| Accession Number: | NM_002831.4; NM_080548.3 |
| Target Name: | SHP-1 |
| Target Aliases: | PTPN6, SHP-1L, HCP, SH-PTP1, PTP1C, PTP-1C, HCPH, SHP1, SHP-1, HPTP1C |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
SHP-1
N-terminal GST-tagged recombinant, human full length SHP-1.
Datasheets
14-591x Datasheet
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