| Biological Information | |
|---|---|
| Background Information: | Raf-1 is the cellular homolog of viral Raf gene (v-Raf). The encoded protein is a MAP Kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
EMBL X03484 |
| Target Class: | Kinase |
| Family: | Ser/Thr Kinase |
| Accession Number: | NM_002880.2 |
| Target Name: | c-RAF |
| Target Aliases: | RAF1, C-RAF, cRaf, Raf-1, c-Raf, CRAF, RAF |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Raf-1 (truncated), active
N-terminal GST-tagged recombinant, human Raf-1 amino acids 306-end, containing the mutations Y340D and Y341D.
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14-352x Datasheet
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