PRK2, active

N-terminal 6His-tagged recombinant, human PRK2 amino acids 501-end.

Catalog #: 14-549

$399.00 – $2,989.00

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Biological Information
Background Information:
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-foes serum response factor (SRF). Involved in the negative regulation of ciliogenesis. GenBank NM_006256
Target Class:
Kinase
Accession Number:
GenBank NM_006256
Target Name:
PRK2
Target Aliases:
PKN2, PRKCL2, STK7, PAK2
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

14-549x Datasheet

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