| Biological Information | |
|---|---|
| Background Information: | Protein kinase RNA-regulated (PKR), an ubiquitous serine/threonine kinase that is induced by interferons, is a critical signal transducer implicated in different stress-induced signaling pathways including dsRNA-induced TLR3 signaling and LPS-induced TLR4 signaling. Upon stress stimulation, PKR is activated by autophosphorylation and subsequently phosphorylates the alpha-subunit of eukaryotic initiation factor 2 (eIF-2a) thereby inducing apoptosis. PKR mediates the activation of important transcription factors, such as NF-kB, and MAP kinases, such as p382, by interacting with the TAK1 complex.
GenBank NM_002759.1 |
| Target Class: | Kinase |
| Accession Number: | NM_002759.1 |
| Target Name: | PKR |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PKR, active
N-terminal GST-tagged and C-terminal 10His tagged recombinant, human PKR amino acids 252-end.
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14-955x Datasheet
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