Biological Information | |
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Background Information: | Protein kinase Cb2 (PKCb2) is one of the major protein kinase C isoforms of a family of serine/threonine protein kinases. Breakdown of phosphatidylinositol leads to formation of diacylglycerol and inositol triphosphate, the former acting synergistically with Ca2+ to activate protein kinase C (PKC), resulting in translocation of the enzyme from cytosol to the membrane. Phosphorylation of proteins by PKC has been implicated as a pivotal regulatory element in signal transduction, cellular regulation, and with a high affinity to phorbol ester tumor promoters.
GenBank X07109 |
Target Class: | Kinase |
Accession Number: | NM_002738.5; NM_212535.1 |
Target Name: | PKCβII |
Target Aliases: | PRKCB1, PRKCB, PRKCB2, PKCB, MGC41878, PKC-B, PKC-beta |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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PKCbetaII, active
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14-496x Datasheet
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