Biological Information | |
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Background Information: | Protein kinase Ca (PKCa) is one of the major protein kinase C isoforms of a family of serine/threonine protein kinases. Breakdown of phosphatidylinositol leads to formation of diacylglycerol and inositol triphosphate, the former acting synergistically with Ca2+ to activate protein kinase C (PKC), resulting in translocation of the enzyme from cytosol to the membrane. Phosphorylation of proteins by PKC has been implicated as a pivotal regulatory element in signal transduction, cellular regulation, and with a high affinity to phorbol ester tumor promoters.
GenBank X52479 |
Target Class: | Kinase |
Accession Number: | NM_002737.2 |
Target Name: | PKCα |
Target Aliases: | PRKCA, PKC-A, PKCA, MGC129901, AAG6, MGC129900, PRKACA, PKC-alpha |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
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PKCalpha, active
Datasheets
14-484x Datasheet
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