| Biological Information | |
|---|---|
| Background Information: | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways. PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication.
GenBank BC053651 |
| Target Class: | Kinase |
| Family: | Lipid Kinase |
| Accession Number: | BC053651 |
| Target Name: | PIK3C3 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
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PIK3C3, active
N-terminal 6His-tagged recombinant, human full length PIK3C3.
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