| Biological Information | |
|---|---|
| Background Information: | PI3K-C2β protein belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and< />intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that< />mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of thisprotein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
GenBank NM_002646 |
| Target Class: | Kinase |
| Family: | Lipid Kinase |
| Accession Number: | NM_002646 |
| Target Name: | PI3KC2β |
| Target Aliases: | PI3-kinase, PIK3, PI3K, PTDINS-3-kinase, PI3K C2b, PI3-Kinase Class II, PIK3C2B |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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PI3K-C2beta
N-terminal 6His-tagged recombinant, human PI3K-C2β, full length.
Datasheets
14-907x Datasheet
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