| Biological Information | |
|---|---|
| Background Information: | PI3K-C2α protein belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
GenBank BC113658 |
| Target Class: | Kinase |
| Family: | Lipid Kinase |
| Accession Number: | NM_002645.2 |
| Target Name: | PI3K-C2α |
| Target Aliases: | PI3-kinase, PIK3, PI3K, PTDINS-3-kinase, PI3K C2a, PI3-Kinase Class II |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PI3K-C2alpha
N-terminal 6His-tagged recombinant, human PI3K-C2α amino acids 299–end.
Datasheets
14-906x Datasheet
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