| Biological Information | |
|---|---|
| Background Information: | PI3 Kinase (p120γ) belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
GenBank AF327656. The recombinant protein contains the amino acid substitution R459Q with respect to this accession number. This conflict is reported in GenBank XM_027912. The residue coordinates in the native sequence are given. |
| Target Class: | Kinase |
| Family: | Lipid Kinase |
| Accession Number: | NM_002649.2 |
| Target Name: | PI3Kγ |
| Target Aliases: | PIK3CG, p110-gamma, PI3-kinase, PIK3, PI3K, PI3Kgamma, PTDINS-3-kinase, PI3CG, p120-PI3K |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PI3 Kinase (p120gamma)
N-terminal 6His-tagged recombinant, human full length PI 3-kinase (p120γ).
Datasheets
14-558x Datasheet
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