| Biological Information | |
|---|---|
| Background Information: | Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.
GenBank NM_005026. The recombinant protein contains the amino acid substitution N253S with respect to this accession number. This conflict is reported in GenBank Y10055 and U57843. The residue coordinates in the native sequence are given / GenBank XM_043865 |
| Target Class: | Kinase |
| Family: | Lipid Kinase |
| Accession Number: | NM_005026.2 |
| Target Name: | PI3Kδ/p85α |
| Target Aliases: | PIK3CD, p110d, PI3K, p110D, p110delta |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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PI3 Kinase (p110delta/p85alpha), active
Complex of N-terminal 6His-tagged recombinant, human full length p110δ and untagged recombinant, human full length p85α.
Datasheets
14-604x Datasheet
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