| Biological Information | |
|---|---|
| Background Information: | Complex of N-terminal 6His-tagged recombinant, murine full length p110α containing the mutation E545K and untagged, recombinant, full length murine p85α. The E545K substitution is associated with a number of human cancers. This residue is conserved between the human and murine sequences of p110α. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. |
| Target Class: | Kinase |
| Family: | Lipid Kinase |
| Accession Number: | NM_006218.2 |
| Target Name: | PI3Kα/p85α |
| Target Aliases: | PIK3CA, PI3K, MGC142161, p110-alpha, MGC142163 |
| Target Species: | Mouse |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PI3 Kinase (p110alpha(E545K)/p85alpha), murine
10 µg of murine PI3 Kinase (p110α(E545K)/p85α). Complex of N-terminal 6His-tagged recombinant, murine full length p110α containing the mutation E545K and untagged, recombinant, full length murine p85α.
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