| Biological Information | |
|---|---|
| Background Information: | PI3 Kinase plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. It also participates in cellular signaling in response to various growth factors and involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. PI3K regulates invadopodia formation through the PDPK1-AKT1 pathway, and participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others. |
| Target Class: | Kinase |
| Family: | Lipid Kinase |
| Accession Number: | NM_006218.2 |
| Target Name: | PI3Kα/p85α |
| Target Aliases: | PIK3CA, PI3K, MGC142161, p110-alpha, MGC142163 |
| Target Species: | Mouse |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PI3 Kinase (p110alpha/p85alpha) murine
Complex of N-terminal 6His-tagged recombinant, murine full length p110αand untagged, recombinant, full length murine p85α.
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14-785x Datasheet
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