| Biological Information | |
|---|---|
| Background Information: | Receptors that are tyrosine protein kinases include those receptors for platelet-derived growth factor (PDGF), insulin, epidermal growth factor (EGF) and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. They are expressed in several cell types and, after activation by growth factor binding, trigger a series of intracellular pathways leading to a wide variety of responses; e.g. differentiation, proliferation, migration and invasion, angiogenesis, survival. Inhibition of PDGFA, Alpha platelet-derived growth factor receptor, PDGF-R-alpha, CD140a antigen) receptor kinase may be useful in the treatment of several tumors.
GenBank M21574 |
| Target Class: | Kinase |
| Family: | Receptor Typosine Kinase (RTK): Growth Factor Receptor |
| Accession Number: | NM_006206.3 |
| Target Name: | PDGFRa |
| Target Aliases: | PDGFRA, CD140a, PDGF-R-alpha, MGC74795, PDGFR2, Rhe-PDGFRA, CD140A |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PDGFRalpha, active
N-terminal 6His-tagged recombinant, human PDGFRα, amino acids 550-end.
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14-467x Datasheet
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