PathHunter® eXpress ACVR1C/ACVR2 Dimerization Assay

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The PathHunter® eXpress ACVR1C/ACVR2 Dimerization Assay measures ligand-induced dimerization of ACVR1C/ACVR2. eXpress kits contain all assay materials: cells, reagents, and plates.

Catalog #: 93-1069E3CP5L

$1,789.00 – $5,989.00

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Biological Information
Background Information:
The PathHunter® ACVR1C/ACVR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. activin B) induced dimerization of ACVR1C/ACVR2 receptors. This product uses EFC technology. The cells included overexpress ACVR1C target protein fused to PK alongside ACVR2 target protein fused to EA. Upon ligand-induced dimerization of ACVR1C/ACVR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Target Class:
Kinase
Family:
Ser/Thr Kinase: Type I Receptor
Sub Family:
Protein Ser/Thr
Accession Number:
NM_145259.2
Target Name:
ACVR1C/ACVR2
Target Aliases:
Activin A receptor, type IC, ACVRLK7, ALK7
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
eXpress Assay Kits
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-301 PathHunter eXpress Dimerization Assay Kit REV3 User Manual

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Datasheets

93-1069E3x Datasheet

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