| Biological Information | |
|---|---|
| Background Information: | p38α/SAPK2a Protein is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP Kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
GenBank L35264 |
| Target Class: | Kinase |
| Family: | Ser/Thr Kinase; MAPK; p38 Family |
| Accession Number: | NM_001315.1; NM_139012.1; NM_139013.1; NM_139014.1 |
| Target Name: | p38α/SAPK2a |
| Target Aliases: | MAPK14, PRKM14, RK, SAPK2A, CSBP1, p38, CSPB1, CSBP, PRKM15, Mxi2, p38ALPHA, MXI2, EXIP, CSBP2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -20°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
p38alpha/SAPK2a, unactive
GST-tagged recombinant, human full length p38α/SAPK2a.
Datasheets
14-252x Datasheet
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