| Biological Information | |
|---|---|
| Background Information: | Stress-activated kinase NUAK2 involved in tolerance to glucose starvation. It induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway
GenBank BC017306.2 |
| Target Class: | Kinase |
| Accession Number: | BC017306.2 |
| Target Name: | NUAK2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
NUAK2, active
N-terminal GST-tagged recombinant, human NUAK2 full length.
Datasheets
15-005x Datasheet
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