| Biological Information | |
|---|---|
| Background Information: | Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidermal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-Jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
GenBank AF074393 |
| Target Class: | Kinase |
| Accession Number: | NM_004755.2; NM_182398.1 |
| Target Name: | MSK1 |
| Target Aliases: | RPS6KA5, RSKL, RLPK, MGC1911, MSK1, MSPK1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -20°C |
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MSK1, active
N-terminal 6His-tagged recombinant, human MSK1 amino acids 2-end.
Datasheets
14-548x Datasheet
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