| Biological Information | |
|---|---|
| Background Information: | MnK2, MAPK Interacting Serine/Threonine Kinase 2, is a member of the calcium/calmodulin-dependent kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex.
GenBank NM_017572 |
| Target Class: | Kinase |
| Accession Number: | NM_017572.3; NM_199054.2 |
| Target Name: | Mnk2 |
| Target Aliases: | MKNK2, GPRK7, Mnk2, MNK2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Mnk2, active
N-terminal 6His-tagged recombinant, human full length Mnk2.
Datasheets
14-664x Datasheet
View Document