| Biological Information | |
|---|---|
| Background Information: | MKK4 is a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis.
EMBL U18310 |
| Target Class: | Kinase |
| Family: | Ser/Thr Kinase; MAPK; STE7 Family |
| Accession Number: | NM_003010.2 |
| Target Name: | MKK4 |
| Target Aliases: | MAP2K4, MKK4, JNKK, MEK4, MAPKK4, JNKK1, SEK1, SERK1, PRKMK4 |
| Target Species: | Mouse |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -20°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
MKK4/SKK1, unactive
N-terminal GST-tagged recombinant, murine MKK4 amino acids 35-397.
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