| Biological Information | |
|---|---|
| Background Information: | MKK3 is a dual specificity protein kinase that belongs to the MAP Kinase family. MKK3 is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of MKK3 is involved in the pathogenesis of Yersina pseudotuberculosis [provided by RefSeq, Jul 2008] |
| Target Class: | Kinase |
| Family: | Ser/Thr Kinase; MAPK; STE7 Family |
| Accession Number: | GenBank NM_002756.4 |
| Target Name: | MKK3 |
| Target Aliases: | Mitogen-Activated Protein Kinase Kinase 3, MAPK/ERK Kinase 3, MAP Kinase Kinase 3, Dual Specificity Mitogen-Activated Protein Kinase Kinase, Stress-Activated Protein Kinase Kinase 2, Dual Specificity Mitogen Activated Protein Kinase Kinase 3, SAPK Kinase 2, EC 2.7.12.2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
MKK3, active
active MKK3. N-terminal GST-tagged, recombinant, full length, human MKK3.
Datasheets
16-037x Datasheet
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