| Biological Information | |
|---|---|
| Background Information: | MEKK3 is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In co-transfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. [provided by RefSeq, Jul 2008] |
| Target Class: | Kinase |
| Family: | Ser/Thr Kinase |
| Accession Number: | GenBank NM_002401.3 |
| Target Name: | MEKK3 |
| Target Aliases: | Mitogen-Activated Protein Kinase Kinase Kinase 3, MAPK/ERK Kinase Kinase 3, MAP/ERK Kinase Kinase 3, MEK Kinase 3, EC 2.7.11.25 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
MEKK3, active
active MEKK3. N-terminal GST-tagged, recombinant, human MEKK3 full length.
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16-015x Datasheet
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