| Biological Information | |
|---|---|
| Background Information: | MAPKAP Kinase 3 is a stress-activated serine/threonine-protein kinase which involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. |
| Target Class: | Kinase |
| Family: | Ser/Thr Kinase |
| Accession Number: | NM_004635.3 |
| Target Name: | MAPKAPK3 |
| Target Aliases: | MAPKAPK3, MAPKAP, MAPKAP3, 3PK, MAPKAPK-3, 3pK |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
MAPKAP Kinase 3, unactive
N-terminal GST-tagged recombinant, human MAPKAP Kinase 3 amino acids 2-end.
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