| Biological Information | |
|---|---|
| Background Information: | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.
GenBank NM_002314 |
| Target Class: | Kinase |
| Accession Number: | NM_002314.2 |
| Target Name: | LIMK1 |
| Target Aliases: | LIMK1, LIMK, LIMK-1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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LIM Kinase 1, unactive
N-terminal 6His-tagged recombinant, human LIM Kinase 1 amino acids 285-638.
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14-659x Datasheet
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