InCELL Hunter™ eXpress RIPK2 Kinase Binding Assay

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The InCELL Hunter™ eXpress RIPK2 Kinase Binding Assay measures target engagement via compound-induced stabilization of RIPK2 target protein. eXpress kits contain all assay materials: cells, reagents, and plates.

Catalog #: 96-0050E1CP0L

$1,789.00 – $5,989.00

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Biological Information
Background Information:
The InCELL Hunter™ eXpress RIPK2 Kinase Binding Assay provides an easy-to-use cell based assay to study small molecule drug candidates that engage with kinases. This kit assesses compound-engagement-based stabilization of RIPK2 via detection of RIPK2 levels. This product uses EFC technology. The cells included overexpress RIPK2 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.
Target Class:
Kinase
Family:
TK-Like Kinase
Sub Family:
Protein Ser/Thr
Accession Number:
NC_000008.11
Target Name:
RIPK2
Target Aliases:
CCK, RICK, RIP2, CARD3, GIG30, CARDIAK
Target Species:
Human
Cell Background:
HEK293
Usage
Product Type:
eXpress Assay Kits
Application:
Target Engagement
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
Ready-to-use eXpress assay kits are intended for in vitro research purposes only. These kits are not suitable for lot release applications. Refer to the ready-to-use bioassay kit format for potency testing in lot release for biologic therapeutics. These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Target Engagement
Detection Method:
Chemiluminescence
Additional Information
Brand:
InCELL Hunter™

User Manuals & Protocols

70-429 InCELL Hunter eXpress Assays User Manual REV0A

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Datasheets

96-0050E1x Datasheet

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