| Biological Information | |
|---|---|
| Background Information: | IKKe is a non-canonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death. |
| Target Class: | Kinase |
| Accession Number: | NM_001193321.1 |
| Target Name: | IKKε |
| Target Aliases: | IKBKE, IKKe, IKKI, KIAA0151 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
IKKepsilon, active
10 µg of active IKKε. N-terminal FLAG, GST-tagged recombinant, human IKKε full length.
Datasheets
14-926x Datasheet
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