| Biological Information | |
|---|---|
| Background Information: | Nuclear factor kappa B (NF-kB) plays a critical role in the inducible expression of a large number of genes involved in immune, inflammatory and apoptotic processes. NF-kB is associated with IkB in cytoplasm, which inhibits NF-kB activity. IkB kinase (IKK), which consists of at least three proteins (IKK-1/a, IKK-2/b, and IKK-3/g), phosphorylates IkB and mediates IkB degradation. Once IkB is removed, NF-kB is free to enter the nucleus of the cell and transcriptionally activate its targeted genes.
GenBank AF080158 |
| Target Class: | Kinase |
| Accession Number: | NM_001556.1 |
| Target Name: | IKKβ |
| Target Aliases: | IKBKB, IKK-B, IKK-beta, FLJ40509, IKKB, IkBKB, NFKBIKB, MGC131801, IKK2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
IKKbeta, active
N-terminal 6His-tagged recombinant, human full-length IKKβ.
Datasheets
14-485x Datasheet
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