EphA4, active

N-terminal 6His-tagged recombinant, human EphA4 amino acids 601-892.

Catalog #: 14-574


Biological Information
Background Information:
Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EPA4 (EphA4, Ephrin type-A receptor 4, Tyrosine-protein kinase receptor SEK, Receptor protein-tyrosine kinase HEK8) can cross-respond to both ephrin-A and -B. In the final stages of embryogenesis, expression of EphA4 is found predominantly within regions of the central nervous system including the cerebral cortex, striatum, thalamus, hippocampus, and ventral spinal cord. EphA4 null mutant mice showed specific defects in the corticospinal tract. Recently, the Eph-ephrin system has been found to be involved in vascular development, angiogenesis, tumor growth and metastasis as well as regulation of smooth muscle contractility, onset of platelet aggregation and to promote onset, growth and stability of the hemostatic plugs. Inhibition of EPA4 may be used in the treatment of various tumors but may delay wound healing. GenBank NM_004438
Target Class:
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Accession Number:
Target Name:
Target Aliases:
EPHA4, Hek8, HEK8, EphA4, TYRO1, SEK
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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14-574x Datasheet

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