| Biological Information | |
|---|---|
| Background Information: | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. CKIa enables protein serine/threonine kinase activity. CK1a is also involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Co-localizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022] |
| Target Class: | Kinase |
| Accession Number: | GenBank L37042.1 |
| Target Name: | CK1α |
| Target Aliases: | CSNK1A1, Casein Kinase 1 Alpha 1, CKIalpha, HLCDGP1, PRO2975, HEL-S-77p |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
CK1a, active
active CK1α. N-terminal FLAG-tagged, N-terminal 6His-tagged, recombinant, human CK1 alpha, full length.
Datasheets
16-050x Datasheet
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