| Biological Information | |
|---|---|
| Background Information: | Checkpoint kinase (CHK) is activated by a broad spectrum of DNA-damaging agents, including DNA-strand-breaking agents such as ionizing radiation and topoisomerase inhibitors, and those agents that cause replication stress such as ultraviolet light, hydroxyurea and 5-fluorouracil. CHK2 might have a redundant and supportive role in checkpoints, but its role in ionizing radiation-induced apoptosis is more prominent. However, its role in other DNA-damage-induced apoptosis mechanisms is less well established. CHK2 inhibitors are expected to sensitize proliferating cells to chemotherapy-induced apoptosis.
GenBank NM 007194 |
| Target Class: | Kinase |
| Accession Number: | NM_007194 |
| Target Name: | CHK2 |
| Target Aliases: | CHEK2, CHK2, RAD53, CDS1, LFS2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
CHK2 (I157T), active
10 µg of active CHK2. N-terminal GST and C-terminal 6His-tagged recombinant, human CHK2, amino acids 5-end, containing the I157T mutation.
Datasheets
14-741x Datasheet
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