| Biological Information | |
|---|---|
| Background Information: | Checkpoint kinase (CHK) is activated by a broad spectrum of DNA-damaging agents, including DNA-strand-breaking agents such as ionizing radiation and topoisomerase inhibitors, and those agents that cause replication stress such as ultraviolet light, hydroxyurea and 5-fluorouracil. CHK2 might have a redundant and supportive role in checkpoints, but its role in ionizing radiation-induced apoptosis is more prominent. However, its role in other DNA-damage-induced apoptosis mechanisms is less well established. CHK2 inhibitors are expected to sensitize proliferating cells to chemotherapy-induced apoptosis.
GenBank NP_009125 |
| Target Class: | Kinase |
| Accession Number: | NP_009125 |
| Target Name: | CHK2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
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CHK2 (hu,5-end, R145W)
N-terminal GST and C-terminal 6His-tagged recombinant human CHK2 amino acids 5–end containing the R145W mutation.
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