| Biological Information | |
|---|---|
| Background Information: | Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV. All CaM kinases are able to phosphorylate nuclear transcription factors in vitro at sites that either activate or repress gene expression. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric, multifunctional serine/threonine protein kinase that is expressed in subanatomic regions of the central and peripheral nervous system, T lymphocytes, and male germ cells. It is frequently localized to the nucleus, where it serves as a mediator of Ca(2+)-dependent gene expression Inhibition of CAMKIV may be useful in the treatment of anxiety and stress-related disorders through decrease in corticoropin-releasing hormone (CRH), several cancers (e.g., small cell lung, hepatocellular, ovarian) and sperm motility.
GenBank D30742 |
| Target Class: | Kinase |
| Family: | CAMK1 family |
| Accession Number: | NM_001744.3 |
| Target Name: | CaMKIV |
| Target Aliases: | CAMK4, MGC36771, CaMK-GR |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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CaM Kinase IV, active
C-terminal 6His-tagged recombinant, human full length CaM Kinase IV.
Datasheets
14-547x Datasheet
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