| Biological Information | |
|---|---|
| Background Information: | Aurora family of kinases, contained at least three proteins (Aurora A, B and C), phosphorylate histone H3 and provide a direct path to the nucleosome. Aurora-B (AURAKB, AIK2, AIM1, ARK2, STK12) is needed for metaphase alignment of chromosomes, sister chromatid separation and cytokinesis. Overexpression of Aurora-B is found in several types of cancer and causes dramatic increases in genomic instability.
GenBank NM_004217 / GenBank NM_020238 |
| Target Class: | Kinase |
| Accession Number: | NM_004217 |
| Target Name: | Aurora-B |
| Target Aliases: | AIM-1, STK12, Aik2, IPL1, Aurora-B, ARK2, aurora-B, AIK2, AIM1, AurB, STK5, aurora-1, STK-1, AURKB |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
Aurora B, active
6His-tagged recombinant, human full length Aurora B and N-terminal GST-tagged recombinant, human INCENP amino acids 821-end.
Datasheets
14-835x Datasheet
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