| Biological Information | |
|---|---|
| Background Information: | Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference to GenBank NM_001184.3. M211T is reported in GenBank XM_001131387.1. |
| Target Class: | Kinase |
| Accession Number: | NM_001184.3; AF451323.1 |
| Target Name: | ATR/ATRIP |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
ATR/ATRIP, active
Recombinant, human FLAG-tagged ATR full length and recombinant, human cMyc-tagged ATRIP full length.
Datasheets
14-953x Datasheet
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