| Biological Information | |
|---|---|
| Background Information: | ALK6 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.
GenBank NM_001203 |
| Target Class: | Kinase |
| Family: | Receptor Tyrosine Kinase (RTK): Type XIX RTK: Leukocyte tyrosine kinase (LTK) Receptor family |
| Accession Number: | NM_001203 |
| Target Name: | ALK6 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
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ALK6, active
N-terminal 6His-tagged recombinant, human ALK6 amino acids 148-end.
Datasheets
14-941x Datasheet
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