| Biological Information | |
|---|---|
| Background Information: | Sirtuin 2 (SIRT2) is a member of the Sirtuin family of NAD+-dependent histone deacetylases (HDACs). These proteins play a key role in epigenetic regulation, which refers to changes in gene expression that are not due to alterations in DNA sequence. SIRT2 is involved in regulating many cellular processes, including cell division, DNA repair, and metabolism. One of the primary functions of SIRT2 is the deacetylation of histones, which are proteins that help package DNA into the compact structure of chromatin.
SIRT2 has been implicated in several diseases, including cancer, neurodegeneration, and metabolic disorders. For example, in cancer, SIRT2 has been shown to have both tumor-promoting and tumor-suppressing effects, depending on the context. In neurodegenerative diseases such as Alzheimer's and Parkinson's, SIRT2 appears to play a role in the aggregation of misfolded proteins. |
| Target Class: | Epigenetic Protein |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | sirtuin 2 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
sirtuin 2
N-terminal 6His-tagged recombinant amino acids 50-356, human Sirtuin 2.
Datasheets
EPI060 Datasheet
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