| Biological Information | |
|---|---|
| Background Information: | SETD8 (SET domain-containing protein 8), also known as PR-Set7, is a histone lysine methyltransferase that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the lysine 20 residue of histone H4 (H4K20), leading to the formation of monomethylated H4K20. SETD8 is a member of the SET domain-containing protein family and is the only known enzyme that specifically methylates H4K20 in a monomethylated form.
SETD8 plays a crucial role in the regulation of DNA replication by methylating H4K20 on newly synthesized chromatin, leading to the recruitment of checkpoint proteins and the maintenance of genomic stability. It also plays a role in the DNA damage response by promoting the recruitment of repair factors to damaged DNA.
SETD8 is an important epigenetic protein with potential therapeutic applications. Its inhibition has been shown to suppress tumor growth and improve the response to chemotherapy in preclinical models of cancer. |
| Target Class: | Epigenetic Protein |
| Accession Number: | NP_065115.3 |
| Target Name: | SETD8 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
SETD8
Recombinant human SETD8 amino acids 186-352.
Datasheets
EPI057 Datasheet
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