Ready-to-Assay™ SUCNR1/GPR91 Succinate Receptor Frozen Cells

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The Ready-to-Assay™ SUCNR1/GPR91 Succinate Receptor Frozen Cells measure SUCNR1 (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.

Catalog #: HTS241RTA Size: 2 vials

$849.00

Biological Information
Background Information:
The Ready-to-Assay™ SUCNR1/GPR91 Succinate Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. succinate) based activation of SUCNR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress SUCNR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of SUCNR1 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.
Target Class:
GPCR
Family:
Succinate Receptor
Accession Number:
NM_033050
Target Name:
GPR91 (SUCNR1)
Target Aliases:
SUCNR1, GPR91, Succinate
Target Species:
Human
Usage
Product Type:
Frozen Cells
Application:
Drug Discovery & Development
Storage Conditions:
Short term (24 h) in vapor phase of liquid nitrogen. Media at 4°C.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Calcium Flux
Detection Method:
Fluorescence
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain
Additional Information
Brand:
ChemiSCREEN™

User Manuals & Protocols

70-427 ChemiSCREEN and ChemiBRITE Cell Lines User Manual REV1

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Datasheets

HTS241RTA Datasheet

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