| Biological Information | |
|---|---|
| Background Information: | The PrecisION® hERG membrane prep is a crude membrane prep with high levels of hERG for use in studying binding affinity of drug candidates (small molecules or biologics) targeting ion channels. This membrane prep enables assessment of ligand binding affinity via detection of levels of radioactivity. It is derived from our proprietary stable recombinant cell lines to ensure high levels of hERG surface expression. PrecisION® membrane preps can be used to screen for ligand binding affinities at hERG using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1mL of 2mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. |
| Target Class: | Ion Channel |
| Family: | Voltage-Gated Potassium Ion Channel (Membranes) |
| Target Name: | hERG |
| Target Aliases: | eag-related protein 1, erg1, ERG-1, ether-a-go-go-related gene potassium channel 1, ether-à-go-go-related gene, HERG, potassium channel, voltage gated eag related subfamily H, member 2, potassium voltage-gated channel, potassium voltage-gated channel, subfamily H (eag-related), member 2 |
| Target Species: | Human |
| Cell Background: | HEK293 |
| Usage | |
| Product Type: | Membrane Preparations |
| Application: | Drug Discovery & Development |
| Storage Conditions: | On receipt of material store at -80°C. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Measures: | Electrophysiology |
| Additional Information | |
| Brand: | PrecisION® |
PrecisION® Recombinant hERG Potassium Ion Channel Membrane Preparation
The PrecisION® Recombinant hERG Potassium Ion Channel Membrane Preparation can be used to measure ligand binding to hERG ion channels via radioligand binding assays. Membrane preps contain 1mL of 2mg/mL frozen membranes.
Datasheets
CYL4039 Datasheet
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